21 March 2016 Coronary calcium visualization using dual energy chest radiography with sliding organ registration
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Abstract
Coronary artery calcification (CAC) is the lead biomarker for atherosclerotic heart disease. We are developing a new technique to image CAC using ubiquitously ordered, low cost, low radiation dual energy (DE) chest radiography (using the two-shot GE Revolution XRd system). In this paper, we proposed a novel image processing method (CorCalDx) based on sliding organ registration to create a bone-image-like, coronary calcium image (CCI) that significantly reduces motion artifacts and improves CAC conspicuity. Experiments on images of a physical dynamic cardiac phantom showed that CorCalDx reduced 73% of the motion artifact area as compared to standard DE over a range of heart rates up to 90 bpm and varying x-ray radiation exposures. Residual motion artifact in the phantom CCI is greatly suppressed in gray level and area (0.88% of the heart area). In a Functional Measurement Test (FMT) with 20 clinical exams, image quality improvement of CorCalDx against standard DE (measured from -10 to +10) was significantly suggested (p<0.0001) by three radiologists for cardiac motion artifacts (7.2±2.1) and cardiac anatomy visibility (6.1±3.5). CorCalDx was always chosen best in every image tested. In preliminary assessments of 12 patients with 18 calcifications, 90% of motion artifact regions in standard DE results were removed in CorCalDx results, with 100% sensitivity of calcification detection, showing great potential of CorCalDx to improve CAC detection and grading in DE chest radiography.
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Di Wen, Di Wen, Katelyn Nye, Katelyn Nye, Bo Zhou, Bo Zhou, Robert C. Gilkeson, Robert C. Gilkeson, David L. Wilson, David L. Wilson, } "Coronary calcium visualization using dual energy chest radiography with sliding organ registration", Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97840W (21 March 2016); doi: 10.1117/12.2216436; https://doi.org/10.1117/12.2216436
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