21 March 2016 Tissue classification of large-scale multi-site MR data using fuzzy k-nearest neighbor method
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This paper describes enhancements to automate classification of brain tissues for multi-site degenerative magnetic resonance imaging (MRI) data analysis. Processing of large collections of MR images is a key research technique to advance our understanding of the human brain. Previous studies have developed a robust multi-modal tool for automated tissue classification of large-scale data based on expectation maximization (EM) method initialized by group-wise prior probability distributions. This work aims to augment the EM-based classification using a non-parametric fuzzy k-Nearest Neighbor (k-NN) classifier that can model the unique anatomical states of each subject in the study of degenerative diseases. The presented method is applicable to multi-center heterogeneous data analysis and is quantitatively validated on a set of 18 synthetic multi-modal MR datasets having six different levels of noise and three degrees of bias-field provided with known ground truth. Dice index and average Hausdorff distance are used to compare the accuracy and robustness of the proposed method to a state-of-the-art classification method implemented based on EM algorithm. Both evaluation measurements show that presented enhancements produce superior results as compared to the EM only classification.
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Ali Ghayoor, Jane S. Paulsen, Regina E. Y. Kim, Hans J. Johnson, "Tissue classification of large-scale multi-site MR data using fuzzy k-nearest neighbor method", Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97841V (21 March 2016); doi: 10.1117/12.2216625; https://doi.org/10.1117/12.2216625

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