24 March 2016 Fusion of multi-parametric MRI and temporal ultrasound for characterization of prostate cancer: in vivo feasibility study
Author Affiliations +
Abstract
Recently, multi-parametric Magnetic Resonance Imaging (mp-MRI) has been used to improve the sensitivity of detecting high-risk prostate cancer (PCa). Prior to biopsy, primary and secondary cancer lesions are identified on mp-MRI. The lesions are then targeted using TRUS guidance. In this paper, for the first time, we present a fused mp-MRI-temporal-ultrasound framework for characterization of PCa, in vivo. Cancer classification results obtained using temporal ultrasound are fused with those achieved using consolidated mp-MRI maps determined by multiple observers. We verify the outcome of our study using histopathology following deformable registration of ultrasound and histology images. Fusion of temporal ultrasound and mp-MRI for characterization of the PCa results in an area under the receiver operating characteristic curve (AUC) of 0.86 for cancerous regions with Gleason scores (GSs)≥3+3, and AUC of 0.89 for those with GSs≥3+4.
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Farhad Imani, Sahar Ghavidel, Purang Abolmaesumi, Siavash Khallaghi, Eli Gibson, Amir Khojaste, Mena Gaed, Madeleine Moussa, Jose A. Gomez, Cesare Romagnoli, Derek W. Cool, Matthew Bastian-Jordan, Zahra Kassam, D. Robert Siemens, Michael Leveridge, Silvia Chang, Aaron Fenster, Aaron D. Ward, Parvin Mousavi, "Fusion of multi-parametric MRI and temporal ultrasound for characterization of prostate cancer: in vivo feasibility study", Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 97851K (24 March 2016); doi: 10.1117/12.2217205; https://doi.org/10.1117/12.2217205
PROCEEDINGS
7 PAGES


SHARE
Back to Top