A semi-automatic framework of measuring pulmonary arterial metrics at anatomic airway locations using CT imaging

Dakai Jin; Junfeng Guo; Timothy M. Dougherty; Krishna S. Iyer; Eric A. Hoffman; Punam K. Saha

doi:10.1117/12.2216558

29 March 2016 A semi-automatic framework of measuring pulmonary arterial metrics at anatomic airway locations using CT imaging

Dakai Jin, Junfeng Guo, Timothy M. Dougherty, Krishna S. Iyer, Eric A. Hoffman, Punam K. Saha

Author Affiliations +

Proceedings Volume 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging; 978816 (2016) https://doi.org/10.1117/12.2216558
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Pulmonary vascular dysfunction has been implicated in smoking-related susceptibility to emphysema. With the growing interest in characterizing arterial morphology for early evaluation of the vascular role in pulmonary diseases, there is an increasing need for the standardization of a framework for arterial morphological assessment at airway segmental levels. In this paper, we present an effective and robust semi-automatic framework to segment pulmonary arteries at different anatomic airway branches and measure their cross-sectional area (CSA). The method starts with user-specified endpoints of a target arterial segment through a custom-built graphical user interface. It then automatically detect the centerline joining the endpoints, determines the local structure orientation and computes the CSA along the centerline after filtering out the adjacent pulmonary structures, such as veins or airway walls. Several new techniques are presented, including collision-impact based cost function for centerline detection, radial sample-line based CSA computation, and outlier analysis of radial distance to subtract adjacent neighboring structures in the CSA measurement. The method was applied to repeat-scan pulmonary multirow detector CT (MDCT) images from ten healthy subjects (age: 21-48 Yrs, mean: 28.5 Yrs; 7 female) at functional residual capacity (FRC). The reproducibility of computed arterial CSA from four airway segmental regions in middle and lower lobes was analyzed. The overall repeat-scan intra-class correlation (ICC) of the computed CSA from all four airway regions in ten subjects was 96% with maximum ICC found at LB10 and RB4 regions.

Citation Download Citation

Dakai Jin, Junfeng Guo, Timothy M. Dougherty, Krishna S. Iyer, Eric A. Hoffman, and Punam K. Saha "A semi-automatic framework of measuring pulmonary arterial metrics at anatomic airway locations using CT imaging", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 978816 (29 March 2016); https://doi.org/10.1117/12.2216558

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available