Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments

Dominique Lunter; Rolf Daniels

doi:10.1117/12.2214850

29 March 2016 Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments

Dominique Lunter, Rolf Daniels

Author Affiliations +

Proceedings Volume 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging; 978829 (2016) https://doi.org/10.1117/12.2214850
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Confocal Raman microscopy has become an advancing technique in the characterization of drug transport into the skin. In this study the skin penetration of a local anesthetic from a semisolid preparation was investigated. Furthermore, the effect of the chemical enhancers propylene glycol and POE-23-lauryl ether on its penetration was investigated. The results show that confocal Raman microscopy may provide detailed information on the penetration of APIs into the skin and may elucidate their distribution within the skin with high resolution. The results of the CRM analysis are fully in line with those of conventional permeation and penetration experiments.

Citation Download Citation

Dominique Lunter and Rolf Daniels "Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 978829 (29 March 2016); https://doi.org/10.1117/12.2214850

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available