29 March 2016 Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments
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Abstract
Confocal Raman microscopy has become an advancing technique in the characterization of drug transport into the skin. In this study the skin penetration of a local anesthetic from a semisolid preparation was investigated. Furthermore, the effect of the chemical enhancers propylene glycol and POE-23-lauryl ether on its penetration was investigated. The results show that confocal Raman microscopy may provide detailed information on the penetration of APIs into the skin and may elucidate their distribution within the skin with high resolution. The results of the CRM analysis are fully in line with those of conventional permeation and penetration experiments.
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Dominique Lunter, Dominique Lunter, Rolf Daniels, Rolf Daniels, "Measuring skin penetration by confocal Raman microscopy (CRM): correlation to results from conventional experiments", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 978829 (29 March 2016); doi: 10.1117/12.2214850; https://doi.org/10.1117/12.2214850
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