25 March 2016 Lesion registration for longitudinal disease tracking in an imaging informatics-based multiple sclerosis eFolder
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Abstract
We have designed and developed a multiple sclerosis eFolder system for patient data storage, image viewing, and automatic lesion quantification results stored in DICOM-SR format. The web-based system aims to be integrated in DICOM-compliant clinical and research environments to aid clinicians in patient treatments and data analysis. The system needs to quantify lesion volumes, identify and register lesion locations to track shifts in volume and quantity of lesions in a longitudinal study. In order to perform lesion registration, we have developed a brain warping and normalizing methodology using Statistical Parametric Mapping (SPM) MATLAB toolkit for brain MRI. Patients’ brain MR images are processed via SPM’s normalization processes, and the brain images are analyzed and warped according to the tissue probability map. Lesion identification and contouring are completed by neuroradiologists, and lesion volume quantification is completed by the eFolder’s CAD program. Lesion comparison results in longitudinal studies show key growth and active regions. The results display successful lesion registration and tracking over a longitudinal study. Lesion change results are graphically represented in the web-based user interface, and users are able to correlate patient progress and changes in the MRI images. The completed lesion and disease tracking tool would enable the eFolder to provide complete patient profiles, improve the efficiency of patient care, and perform comprehensive data analysis through an integrated imaging informatics system.
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Kevin Ma, Kevin Ma, Joseph Liu, Joseph Liu, Xuejun Zhang, Xuejun Zhang, Alex Lerner, Alex Lerner, Mark Shiroishi, Mark Shiroishi, Lilyana Amezcua, Lilyana Amezcua, Brent Liu, Brent Liu, } "Lesion registration for longitudinal disease tracking in an imaging informatics-based multiple sclerosis eFolder", Proc. SPIE 9789, Medical Imaging 2016: PACS and Imaging Informatics: Next Generation and Innovations, 97890F (25 March 2016); doi: 10.1117/12.2217903; https://doi.org/10.1117/12.2217903
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