1 April 2016 Quantitative head ultrasound measurements to determine thresholds for preterm neonates requiring interventional therapies following intraventricular hemorrhage
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Proceedings Volume 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography; 97900S (2016); doi: 10.1117/12.2216870
Event: SPIE Medical Imaging, 2016, San Diego, California, United States
Abstract
Dilation of the cerebral ventricles is a common condition in preterm neonates with intraventricular hemorrhage (IVH). This post hemorrhagic ventricle dilation (PHVD) can lead to lifelong neurological impairment through ischemic injury due to increased intracranial pressure and without treatment, can lead to death.

Clinically, 2D ultrasound (US) through the fontanelles ('soft spots') of the patients are serially acquired to monitor the progression of the ventricle dilation. These images are used to determine when interventional therapies such as needle aspiration of the built up cerebrospinal fluid (CSF) ('ventricle tap', VT) might be indicated for a patient; however, quantitative measurements of the growth of the ventricles are often not performed. There is no consensus on when a neonate with PHVD should have an intervention and often interventions are performed after the potential for brain damage is quite high.

Previously we have developed and validated a 3D US system to monitor the progression of ventricle volumes (VV) in IVH patients.

We will describe the potential utility of quantitative 2D and 3D US to monitor and manage PHVD in neonates. Specifically, we will look to determine image-based measurement thresholds for patients who will require VT in comparison to patients with PHVD who resolve without intervention. Additionally, since many patients who have an initial VT will require subsequent interventions, we look at the potential for US to determine which PHVD patients will require additional VT after the initial one has been performed.
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Jessica Kishimoto, Aaron Fenster, Fateme Salehi, Walter Romano, David S. C. Lee, Sandrine de Ribaupierre, "Quantitative head ultrasound measurements to determine thresholds for preterm neonates requiring interventional therapies following intraventricular hemorrhage", Proc. SPIE 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography, 97900S (1 April 2016); doi: 10.1117/12.2216870; http://dx.doi.org/10.1117/12.2216870
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KEYWORDS
Ultrasonography

3D image processing

Image segmentation

Head

Therapeutics

Transducers

Imaging systems

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