Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica

Hui-Chen Tsai; Chun-Fang Chang; Bi-Chang Chen; Ji-Yen Cheng; Chih-Wei Chu; Hsieh-Cheng Han; Koji Hatanaka; Tung-Han Hsieh; Chau-Hwang Lee; Jung-Hsin Lin; Yi-Chung Tung; Pei-Kuen Wei; Fu-Liang Yang; Din Ping Tsai

doi:10.1117/12.2199475

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9 December 2015 Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica

Hui-Chen Tsai, Chun-Fang Chang, Bi-Chang Chen, Ji-Yen Cheng, Chih-Wei Chu, Hsieh-Cheng Han, Koji Hatanaka, Tung-Han Hsieh, Chau-Hwang Lee, Jung-Hsin Lin, Yi-Chung Tung, Pei-Kuen Wei, Fu-Liang Yang, Din Ping Tsai

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Proceedings Volume 9792, Biophotonics Japan 2015; 979212 (2015) https://doi.org/10.1117/12.2199475
Event: SPIE/OSJ Biophotonics Japan, 2015, Tokyo, Japan

Abstract

Development of imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS) of Academia Sinica in Taiwan is progressing rapidly. The research on advanced lattice light sheet microscopy for temporal visualization of cells in three dimensions at sub-cellular resolution shows novel imaging results. Label-free observation on filopodial dynamics provides a convenient assay on cancer cell motility. The newly-developed software enables us to track the movement of two types of particles through different channels and reconstruct the co-localized tracks. Surface plasmon resonance (SPR) for detecting urinary microRNA for diagnosis of acute kidney injury demonstrates excellent sensitivity. A fully automated and integrated portable reader was constructed as a home-based surveillance system for post-operation hepatocellular carcinoma. New microfluidic cell culture devices for fast and accurate characterizations prove various diagnosis capabilities.

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Hui-Chen Tsai, Chun-Fang Chang, Bi-Chang Chen, Ji-Yen Cheng, Chih-Wei Chu, Hsieh-Cheng Han, Koji Hatanaka, Tung-Han Hsieh, Chau-Hwang Lee, Jung-Hsin Lin, Yi-Chung Tung, Pei-Kuen Wei, Fu-Liang Yang, and Din Ping Tsai "Research on imaging, sensing, and characterization of cells at Research Center for Applied Sciences (RCAS), Academia Sinica", Proc. SPIE 9792, Biophotonics Japan 2015, 979212 (9 December 2015); https://doi.org/10.1117/12.2199475

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