Nano-structure of soft and wet materials are making important roles in radiation therapy, as a three-dimensional (3D) gel dosimeter. In the last decades, radiation therapy instruments have had a large progressive of the accuracy, therefore more precise measurements have became important. We study new materials and apparatus, which measure three dimensional absorbed dose distributions. New materials are double network (DN2) gel and improved PAGAT (yDAGAT) gel, the former has several good points, high transparency, high water content, high mechanical strength, and toughness, the later has similar properties of PAGAT gel but will be more tractable. The new type of optical-CT machine is Scanning Microscopic Light Scattering System (SMILS). Usual optical-CT uses the opacity, which is measured by the intensity, however SMILS also uses dynamic light scattering (DLS) theory with original ensemble average method. By using the intensity and DLS information, more accurate information are expected. We have established one-dimensional measurement by SMILS using irradiated DN gel. Additionally, yDAGAT is successfully composed. In the future, we are planning to develop three-dimensional radiation measurement apparatus by 3D printable gel and 3D SMILS.