The numerical solution of the problem is carried out with the use of an implicit difference scheme and the sweep method. Two cases of the laser pulse action on a particle are considered: a single pulse and a series of pulses. The dynamics of the temperature isoline propagation is obtained at which protein denaturation occurs in the space around the metal nanoparticle in the cases when the particles are heated by a single pulse and a series of pulses. The dependence of the heating rate and the heating depth of the medium on the laser pulse repetition frequency is found.
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A. Yu. Krainov, K. M. Moiseeva, A. V. Shapovalov, "Thermal interaction of biological tissue with nanoparticles heated by laser radiation," Proc. SPIE 9810, International Conference on Atomic and Molecular Pulsed Lasers XII, 981020 (15 December 2015);