Early detection and longitudinal imaging of cancer micrometastases using biofunctionalized rare-earth albumin nanocomposites

M. Zevon; H. Kantamneni; V. Ganapathy; L. Higgins; M. Mingozzi; M. Pierce; R. Riman; C. M. Roth; P. V. Moghe

doi:10.1117/12.2224678

17 May 2016 Early detection and longitudinal imaging of cancer micrometastases using biofunctionalized rare-earth albumin nanocomposites

M. Zevon, H. Kantamneni, V. Ganapathy, L. Higgins, M. Mingozzi, M. Pierce, R. Riman, C. M. Roth, P. V. Moghe

Author Affiliations +

Proceedings Volume 9836, Micro- and Nanotechnology Sensors, Systems, and Applications VIII; 98361P (2016) https://doi.org/10.1117/12.2224678
Event: SPIE Defense + Security, 2016, Baltimore, MD, United States

Abstract

Success of personalized medicine in cancer therapy depends on the ability to identify and molecularly phenotype tumors. Current clinical imaging techniques cannot be integrated with precision molecular medicine at the level of single cells or microlesions due to limited resolution. In this work we use molecularly targeted infrared emitting optical probes to identify and characterize metastatic microlesions prior to their detection with clinically relevant imaging modalities. These contrast agents form the basis of an in vivo optical imaging system capable of resolving internal microlesions, filling a critical unmet need in cancer imaging.

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M. Zevon, H. Kantamneni, V. Ganapathy, L. Higgins, M. Mingozzi, M. Pierce, R. Riman, C. M. Roth, and P. V. Moghe "Early detection and longitudinal imaging of cancer micrometastases using biofunctionalized rare-earth albumin nanocomposites", Proc. SPIE 9836, Micro- and Nanotechnology Sensors, Systems, and Applications VIII, 98361P (17 May 2016); https://doi.org/10.1117/12.2224678

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