Hyperspectral imagery (HSI) oﬀers numerous advantages over traditional sensing modalities with its high spectral content that allows for classiﬁcation, anomaly detection, target discrimination, and change detection. However, this imaging modality produces a huge amount of data, which requires transmission, processing, and storage resources; hyperspectral compression is a viable solution to these challenges. It is well known that lossy compression of hyperspectral imagery can impact hyperspectral target detection. Here we examine lossy compressed hyperspectral imagery from data-centric and target-centric perspectives. The compression ratio (CR), root mean square error (RMSE), the signal to noise ratio (SNR), and the correlation coeﬃcient are computed directly from the imagery and provide insight to how the imagery has been aﬀected by the lossy compression process. With targets present in the imagery, we perform target detection with the spectral angle mapper (SAM) and adaptive coherence estimator (ACE) and evaluate the change in target detection performance by examining receiver operating characteristic (ROC) curves and the target signal-to-clutter ratio (SCR). Finally, we observe relationships between the data- and target-centric metrics for selected visible/near-infrared to shortwave infrared (VNIR/SWIR) HSI data, targets, and backgrounds that motivate potential prediction of change in target detection performance as a function of compression ratio.