13 May 2016 Characterization of analytical figures of merit of a sub-diffraction limited fiber bundle array for SERS imaging
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Super resolution chemical imaging can provide high spatial resolution images that contain chemically specific information. Additionally, using a technique such as Raman scattering provides molecular specific information based on the inherent vibrations within the analyte of interest. In this work, commercially available fiber bundle arrays (1mm diameter) consisting of 30,000 individual fiber elements (4μm diameter) that are then modified to obtain surface enhanced Raman scatter are employed. This allows for the visualization of vibrational information with high spatial (i.e. sub-diffraction limited) resolution over the 30,000 individual points of interrogation covering a total imaging diameter of approximately 20μm in a non-scanning format. Using these bundles, it has been shown that dithering can increase the spatial resolution of the arrays further by obtaining several sub-element shifted images. To retain the spatial resolution of such images, cross talk associated with these tpared bundles must be kept at a negligible level.

In this paper, a study of luminescent particles isolated in individual fiber wells has been performed to characterize the cross talk associated with these fiber bundles. Scanning-electron microscope (SEM) images provide nanometric characterization of the fiber array, while luminescent signals allow for the quantitation of cross talk between adjacent fiber elements. From these studies negligible cross-talk associated with both untapered and tapered bundles was found to exist.
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Eric R. Languirand, Eric R. Languirand, Brian M. Cullum, Brian M. Cullum, "Characterization of analytical figures of merit of a sub-diffraction limited fiber bundle array for SERS imaging", Proc. SPIE 9863, Smart Biomedical and Physiological Sensor Technology XIII, 98630C (13 May 2016); doi: 10.1117/12.2220593; https://doi.org/10.1117/12.2220593

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