27 April 2016 Fluorescence spectroscopy for neoplasms control
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Abstract
Investigation of malignant skin tumors diagnosis was performed involving two setups for native tissues fluorescence control in visible and near infrared regions. Combined fluorescence analysis for skin malignant melanomas and basal cell carcinomas was performed. Autofluorescence spectra of normal skin and oncological pathologies stimulated by 457 nm and 785 nm lasers were registered for 74 skin tissue samples. Spectra of 10 melanomas and 27 basal cell carcinomas were registered ex vivo. Skin tumors analysis was made on the basis of autofluorescence spectra intensity and curvature for analysis of porphyrins, lipo-pigments, flavins and melanin. Separation of melanomas and basal cell carcinomas was performed on the basis of discriminant analysis. Overall accuracy of basal cell carcinomas and malignant melanomas separation in current study reached 86.5% with 70% sensitivity and 92.6% specificity.
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I. A. Bratchenko, Yu. A. Kristoforova, O. O. Myakinin, D. N. Artemyev, S. V. Kozlov, A. A. Moryatov, V. P. Zakharov, "Fluorescence spectroscopy for neoplasms control", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 98870Y (27 April 2016); doi: 10.1117/12.2227610; https://doi.org/10.1117/12.2227610
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