Noncontact blood perfusion mapping in clinical applications

Dmitry Iakovlev; Vincent Dwyer; Sijung Hu; Vadim Silberschmidt

doi:10.1117/12.2225216

Abstract

Non-contact imaging photoplethysmography (iPPG) to detect pulsatile blood microcirculation in tissue has been selected as a successor to low spatial resolution and slow scanning blood perfusion techniques currently employed by clinicians. The proposed iPPG system employs a novel illumination source constructed of multiple high power LEDs with narrow spectral emission, which are temporally modulated and synchronised with a high performance sCMOS sensor. To ensure spectrum stability and prevent thermal wavelength drift due to junction temperature variations, each LED features a custom-designed thermal management system to effectively dissipate generated heat and auto-adjust current flow. The use of a multi-wavelength approach has resulted in simultaneous microvascular perfusion monitoring at various tissue depths, which is an added benefit for specific clinical applications. A synchronous detection algorithm to extract weak photoplethysmographic pulse-waveforms demonstrated robustness and high efficiency when applied to even small regions of 5 mm². The experimental results showed evidences that the proposed system could achieve noticeable accuracy in blood perfusion monitoring by creating complex amplitude and phase maps for the tissue under examination.

Citation Download Citation

Dmitry Iakovlev, Dmitry Iakovlev, Vincent Dwyer, Vincent Dwyer, Sijung Hu, Sijung Hu, Vadim Silberschmidt, Vadim Silberschmidt, } "Noncontact blood perfusion mapping in clinical applications", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988712 (27 April 2016); doi: 10.1117/12.2225216; https://doi.org/10.1117/12.2225216

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