27 April 2016 Noncontact blood perfusion mapping in clinical applications
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Abstract
Non-contact imaging photoplethysmography (iPPG) to detect pulsatile blood microcirculation in tissue has been selected as a successor to low spatial resolution and slow scanning blood perfusion techniques currently employed by clinicians. The proposed iPPG system employs a novel illumination source constructed of multiple high power LEDs with narrow spectral emission, which are temporally modulated and synchronised with a high performance sCMOS sensor. To ensure spectrum stability and prevent thermal wavelength drift due to junction temperature variations, each LED features a custom-designed thermal management system to effectively dissipate generated heat and auto-adjust current flow. The use of a multi-wavelength approach has resulted in simultaneous microvascular perfusion monitoring at various tissue depths, which is an added benefit for specific clinical applications. A synchronous detection algorithm to extract weak photoplethysmographic pulse-waveforms demonstrated robustness and high efficiency when applied to even small regions of 5 mm2. The experimental results showed evidences that the proposed system could achieve noticeable accuracy in blood perfusion monitoring by creating complex amplitude and phase maps for the tissue under examination.
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Dmitry Iakovlev, Dmitry Iakovlev, Vincent Dwyer, Vincent Dwyer, Sijung Hu, Sijung Hu, Vadim Silberschmidt, Vadim Silberschmidt, } "Noncontact blood perfusion mapping in clinical applications", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988712 (27 April 2016); doi: 10.1117/12.2225216; https://doi.org/10.1117/12.2225216
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