Gold nanocages for imaging and therapy of prostate cancer cells

Laura Sironi; Svetlana Avvakumova; Elisabetta Galbiati; Silvia A. Locarno; Chiara Macchi; Laura D'Alfonso; Massimiliano Ruscica; Paolo Magni; Maddalena Collini; Sergio Romeo; Giuseppe Chirico; Davide Prosperi

doi:10.1117/12.2229715

27 April 2016 Gold nanocages for imaging and therapy of prostate cancer cells

Laura Sironi, Svetlana Avvakumova, Elisabetta Galbiati, Silvia A. Locarno, Chiara Macchi, Laura D'Alfonso, Massimiliano Ruscica, Paolo Magni, Maddalena Collini, Sergio Romeo, Giuseppe Chirico, Davide Prosperi

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Proceedings Volume 9887, Biophotonics: Photonic Solutions for Better Health Care V; 988721 (2016) https://doi.org/10.1117/12.2229715
Event: SPIE Photonics Europe, 2016, Brussels, Belgium

Abstract

Gold nanocages (AuNCs) have been shown to be a useful tool both for imaging and hyperthermia therapy of cancer, thanks to their outstanding optical properties, low toxicity and facile functionalization with targeting molecules, including peptides and antibodies. In particular, hyperthermia is a minimally invasive therapy which takes advantage of the peculiar properties of gold nanoparticles to efficiently convert the absorbed light into heat. Here, we use AuNCs for the selective targeting and imaging of prostate cancer cells. Moreover, we report the hyperthermic effect characterization of the AuNCs both in solution and internalized in cells. Prostate cancer cells were irradiated at different exposure times, with a pulsed near infrared laser, and the cellular viability was evaluated by confocal microscopy.

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Laura Sironi, Svetlana Avvakumova, Elisabetta Galbiati, Silvia A. Locarno, Chiara Macchi, Laura D'Alfonso, Massimiliano Ruscica, Paolo Magni, Maddalena Collini, Sergio Romeo, Giuseppe Chirico, and Davide Prosperi "Gold nanocages for imaging and therapy of prostate cancer cells", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988721 (27 April 2016); https://doi.org/10.1117/12.2229715

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KEYWORDS

Gold

Luminescence

Nanoparticles

Prostate cancer

Confocal microscopy

Near infrared

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