The study of binary stars is critical to apprehend many of the most interesting classes of stars. Moreover, quite often, the study of stars in binary systems is our only mean to constrain stellar properties, such as masses and radii. Unfortunately, a great fraction of the most interesting binaries are so compact that they can only be apprehended by high-resolution techniques, mostly by interferometry. I present some results highlighting the use of interferometry in the study of binary stars, from finding companions and deriving orbits, determining the mass and radius of stars, to studying mass transfer in symbiotic stars, and tackling luminous blue variables. In particular, I show how interferometric studies using the PIONIER instrument have allowed us to confirm a dichotomy within symbiotic stars, obtain masses of stars with a precision better than 1%, and help us find a new η Carinae-like system. I will also illustrate the benefits for the study of binary stars one would get from upgrading the VLT Interferometer so as to be able to observe in the visible range.