Processing astronomical data to science readiness was and remains a challenge, in particular in the case of multi detector instruments such as wide-field imagers. One such instrument, the WIYN One Degree Imager, is available to the astronomical community at large, and, in order to be scientifically useful to its varied user community on a short timescale, provides its users fully calibrated data in addition to the underlying raw data. However, time-efficient re-processing of the often large datasets with improved calibration data and/or software requires more than just a large number of CPU-cores and disk space. This is particularly relevant if all computing resources are general purpose and shared with a large number of users in a typical university setup. Our approach to address this challenge is a flexible framework, combining the best of both high performance (large number of nodes, internal communication) and high throughput (flexible/variable number of nodes, no dedicated hardware) computing. Based on the Advanced Message Queuing Protocol, we a developed a Server-Manager- Worker framework. In addition to the server directing the work flow and the worker executing the actual work, the manager maintains a list of available worker, adds and/or removes individual workers from the worker pool, and re-assigns worker to different tasks. This provides the flexibility of optimizing the worker pool to the current task and workload, improves load balancing, and makes the most efficient use of the available resources. We present performance benchmarks and scaling tests, showing that, today and using existing, commodity shared- use hardware we can process data with data throughputs (including data reduction and calibration) approaching that expected in the early 2020s for future observatories such as the Large Synoptic Survey Telescope.