21 April 2016 Pilot in vivo animal study of bone regeneration by fractional Er: YAG-laser
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The histological structure of the rabbit parietal bone during its regeneration after fractional Er: YAG-laser (λ=2.94μm) treatment was investigated by hematoxylin and eosin (H&E) stain. In 48 days after fractional laser treatment, bone samples contained micro-cavities and fragments of necrotic tissue with empty cellular lacuna and coagulated protein of bone matrix. In this case, necrotic lesions appeared around the periphery of micro-cavities created by laser radiation. Fragmentation of detrital mass and partial substitution of micro-cavities with fatty bone marrow were observed in bone samples in 100 days after fractional laser treatment, in contrast to the earlier period. Partial filling of micro-cavities edges by fibrous tissue with presence of osteoblasts on their inner surface was observed in 100 days also, that indicates regenerative processes in the bone.
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Gregory B. Altshuler, Gregory B. Altshuler, Andrey V. Belikov, Andrey V. Belikov, Ksenia V. Shatilova, Ksenia V. Shatilova, Andrey I. Yaremenko, Andrey I. Yaremenko, Alexander Y. Zernitskiy, Alexander Y. Zernitskiy, Ekaterina A. Zernitckaia, Ekaterina A. Zernitckaia, } "Pilot in vivo animal study of bone regeneration by fractional Er: YAG-laser", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 991702 (21 April 2016); doi: 10.1117/12.2229391; https://doi.org/10.1117/12.2229391

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