21 April 2016 The morphological changes in transplanted tumors in rats at plasmonic photothermal therapy
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Abstract
The aim of work was to study the morphological changes in transplanted liver tumors of rats after plasmonic photothermal therapy (PPTT). The gold nanorods functionalized with thiolated polyethylene glycol were injected intravenously to rats with transplanted liver cancer PC-1. A day after injection the tumors were irradiated by the infrared 808-nm diode laser. The withdrawal of the animals from the experiment and sampling of tumor tissue for morphological study were performed 24 hours after the laser exposure. The standard histological and immunohistochemical staining with antibodies to proliferation marker Ki-67 and apoptosis marker BAX were used for morphological study of transplanted tumors. The plasmonic photothermal therapy had pronounced damaging effect in rats with transplanted liver tumors expressed in degenerative and necrotic changes in the tumor cells. The decrease of proliferation marker Ki-67 and increase of expression of apoptosis marker BAX were observed in tumor cells after PPTT.
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Alla B Bucharskaya, Alla B Bucharskaya, Galina N. Maslyakova, Galina N. Maslyakova, Nikita A. Navolokin, Nikita A. Navolokin, Nataliya I. Dikht, Nataliya I. Dikht, Georgy S. Terentyuk, Georgy S. Terentyuk, Alexey N. Bashkatov, Alexey N. Bashkatov, Elina A. Genina, Elina A. Genina, Boris N. Khlebtsov, Boris N. Khlebtsov, Nikolai G. Khlebtsov, Nikolai G. Khlebtsov, Valery V. Tuchin, Valery V. Tuchin, } "The morphological changes in transplanted tumors in rats at plasmonic photothermal therapy", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 991708 (21 April 2016); doi: 10.1117/12.2229873; https://doi.org/10.1117/12.2229873
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