21 April 2016 The sex differences in nature of vascular endothelial stress: nitrergic mechanisms
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Here we studied the role of nitric oxide in cardiovascular regulation in male and female hypertensive rats under normal and stress conditions. We found that the severity of hypertension in females was lower than in males. Hypertensive females demonstrated more favorable pattern of cardiovascular responses to stress. Nitric oxide blockade by NG-nitro-L-arginine methyl ester (L-NAME) increased the mean arterial pressure and decreased the heart rate more effectively in females than in males. During stress, L-NAME modified the stress-induced cardiovascular responses more significantly in female compared with male groups. Our data show that hypertensive females demonstrated the more effective nitric oxide control of cardiovascular activity under normal and especially stress conditions than male groups. This sex differences may be important mechanism underlying greater in females vs. males stress-resistance of cardiovascular system and hypertension formation.
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Sergey Sindeev, Sergey Sindeev, Artem Gekaluyk, Artem Gekaluyk, Maria Ulanova, Maria Ulanova, Ilana Agranovich, Ilana Agranovich, Ali Esmat Sharref, Ali Esmat Sharref, Oxana Semyachkina-Glushkovskaya, Oxana Semyachkina-Glushkovskaya, "The sex differences in nature of vascular endothelial stress: nitrergic mechanisms", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99170B (21 April 2016); doi: 10.1117/12.2225471; https://doi.org/10.1117/12.2225471

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