21 April 2016 Photosensitizer fluorescence dynamics at its diffusion in blood flow for different means of cells concentrations
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Abstract
In the paper the mathematical model of kinetics of interaction of the injected compound with biological liquid flow has been described for different means of cells concentrations connected on packed cell volume. It is considered that biological liquid contains a three phases such as water, peptides and cells. At the time, the injected compound can interact with peptides and cells which are "trap" for him. The obtained distribution of the compound connects on changes of its fluorescence spectra. It is shown that fluorescence intensivity change is different at 560, 580 and 590 nm. The curves do not have monotonic nature. There is a sharp curves decline in the first few seconds, next, it are increasing. Curves inflection time slightly depends on the cells concentration and is 7-9 seconds. At the time stationary concentration significantly depends on this parameter in contrast to blood viscosity. As long s cells concentration is primarily mean of the packed cell volume, the model can be important for pharmacokinetics and preparations delivery. It can be also used for fluorescent biomedical diagnostics of cancer tumour.
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V. S. Maryakhina, V. S. Maryakhina, V. V. Gun’kov, V. V. Gun’kov, } "Photosensitizer fluorescence dynamics at its diffusion in blood flow for different means of cells concentrations", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99170E (21 April 2016); doi: 10.1117/12.2229448; https://doi.org/10.1117/12.2229448
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