21 April 2016 Incorporation of iodine in polymeric microparticles and emulsions
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Abstract
Application of different methods for formation of microcontainers containing iodine is proposed in this paper. Two types of microcontainers: microemulsions and microparticles have been investigated, conditions and methods for obtaining microcontainers were optimized.

Microparticles were formed by layer-by-layer method with cores of calcium carbonate (CaCO3) as templates. Incorporation of complexes of iodine with polymers (chitosan, starch, polyvinyl alcohol) into core, shell and hollow capsules was investigated and loadings of microparticles with iodine were estimated. It was found that the complex of iodine with chitosan adsorbed at CaCO3 core is the most stable under physiological conditions and its value of loading can be 450 μg of I2 per 1 g of CaCO3. Moreover, chitosan was chosen as a ligand because of its biocompatibility and biodegradability as well as very low toxicity while its complex with iodine is very stable. A small amount of microparticles containing a iodine–chitosan complex can be used for prolonged release of iodine in the human body since iodine daily intake for adults is around 100 μg.

"Oil-in-water" emulsions were prepared by ultrasonication of iodinated oils (sunflower and linseed) with sodium laurilsulfate (SLS) as surfactant solution. At optimal conditions, the homogenous emulsions remained stable for weeks, with total content of iodine in such emulsion being up to 1% (w/w). The oil:SLS ratio was equal to 1:10 (w/w), optimal duration and power of ultrasound exposure were 1.5 min and 7 W, correspondingly. Favorable application of iodized linseed oil for emulsion preparation with suitable oil microdroplets size was proved.
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Olga A. Kolontaeva, Olga A. Kolontaeva, Anastasia R. Khokhlova, Anastasia R. Khokhlova, Natalia E. Markina, Natalia E. Markina, Alexey V. Markin, Alexey V. Markin, Natalia A. Burmistrova, Natalia A. Burmistrova, } "Incorporation of iodine in polymeric microparticles and emulsions", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171B (21 April 2016); doi: 10.1117/12.2229862; https://doi.org/10.1117/12.2229862
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