21 April 2016 The study of the structural features of the lymphocytes in patients with diabetes using atomic force microscopy
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Abstract
The results of the study of morphological and biophysical parameters of the cell membrane of live lymphocytes in patients with insulin-dependent and non-insulin dependent diabetes mellitus and healthy donors using atomic force microscopy have been presented. It is found that lymphocytes from patients with diabetes are characterized by a decrease in volume and cell surface roughness compared to normal lymphocytes. An increase in the Young's modulus of lymphocytes in patients with diabetes more than 3 times compared to normal rates has been shown. Increased stiffening of lymphocyte cytolemma in patients with non-insulin dependent diabetes mellitus leads to a decrease in its adhesive properties, unlike lymphocytes in patients with insulin-dependent diabetes mellitus.
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Olga V. Stolbovskaya, Radik M. Khairullin, Boris B. Kostishko, Ekaterina S. Pchelintseva, Ekaterina S. Krasnikova, Aleksandr A. Fomin, Aleksandr A. Skaptsov, "The study of the structural features of the lymphocytes in patients with diabetes using atomic force microscopy", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171P (21 April 2016); doi: 10.1117/12.2229609; https://doi.org/10.1117/12.2229609
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