21 April 2016 In vitro metabolism study of normal and tumor cells when exposed to red LED light
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Abstract
This work presents the results of studying the mitochondrial membrane potential, intracellular ROS, peculiarities of the cell cycle of cancer cells HCT-116 and the normal line of CHO cells when exposed to the red LED light with a wavelength range of 0.620-0.680 μm. A dose-dependent increase in mitochondrial membrane potential and intracellular ROS concentration in cancer cells HCT-116 was established. In normal CHO cell line a dose-dependent reduction of mitochondrial membrane potential and dose-dependent increase in intracellular ROS occur. It has been shown that the sensitivity of the studied cell lines to the red light depends on the stage of the cell cycle.
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Olga V. Stolbovskaya, Olga V. Stolbovskaya, Radik M. Khairullin, Radik M. Khairullin, Yuri V. Saenko, Yuri V. Saenko, Ekaterina S. Krasnikova, Ekaterina S. Krasnikova, Aleksandr V. Krasnikov, Aleksandr V. Krasnikov, Aleksandr A. Fomin, Aleksandr A. Fomin, Aleksandr A. Skaptsov, Aleksandr A. Skaptsov, "In vitro metabolism study of normal and tumor cells when exposed to red LED light", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171Q (21 April 2016); doi: 10.1117/12.2229614; https://doi.org/10.1117/12.2229614
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