21 April 2016 Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability
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Recently proposed in vivo label-free optical coherence angiography techniques based on phase and amplitude speckle variability often require additional signal pre- and post processing operations to enhance vessel-contrast. We observe here 1) contrast enhancement by optimizing the signal normalization/weighing before processing; 2) algorithm based on Kasai estimator for phase compensation between processed A-scans to reduce masking role of motion artifacts; and 3) image projection through the imaging depth for en face plotting. We demonstrate the efficiency of proposed additional algorithms as for the microcirculation imaging of hamsters cheek in vivo as for the preliminary microcirculation imaging of patients after radiotherapy. This technical framework complete in details our recent publications on M-Mode like OCT algorithms and its implementation.
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Lev A. Matveev, Lev A. Matveev, Valentin Demidov, Valentin Demidov, Alexander A. Moiseev, Alexander A. Moiseev, Grigory V. Gelikonov, Grigory V. Gelikonov, Alexandr L. Matveyev, Alexandr L. Matveyev, Valentin M. Gelikonov, Valentin M. Gelikonov, Maria M. Karabut, Maria M. Karabut, Ekaterina V. Gubarkova, Ekaterina V. Gubarkova, Elena S. Finagina, Elena S. Finagina, Marina A. Sirotkina, Marina A. Sirotkina, Anna V. Maslennikova, Anna V. Maslennikova, Natalia D. Gladkova, Natalia D. Gladkova, Alex Vitkin, Alex Vitkin, Vladimir Yu. Zaitsev, Vladimir Yu. Zaitsev, "Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171S (21 April 2016); doi: 10.1117/12.2229740; https://doi.org/10.1117/12.2229740

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