21 April 2016 Micro-PIV quantification of capillary blood flow redistribution caused by laser-assisted vascular occlusion
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Abstract
We propose μPIV-based technique for quantitative assessment of blood flow redistribution in microcirculatory networks. Our approach is based on per-segment averaging of measured quantities so we can avoid most of problems that are typical for point-wise measurements. The key point of our technique is the digital processing algorithms of recorded data that include: capillary network axial line construction; interrogation regions centering; blood flow velocity local estimate using PIV approach; blood flow velocity calculation by means of averaging over entire vessel segment; the calculation of blood volume flow rate map. We illustrate the application of developed technique with in vivo measurements and blood flow velocity map reconstruction for chorioallantoic membrane (CAM) of chicken embryo, in which the local vascular occlusion was produced using continuous wave laser light irradiation..
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Maxim A. Kurochkin, Elena S. Stiukhina, Ivan V. Fedosov, Dmitry E. Postnov, Valery V. Tuchin, "Micro-PIV quantification of capillary blood flow redistribution caused by laser-assisted vascular occlusion ", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99171T (21 April 2016); doi: 10.1117/12.2229766; https://doi.org/10.1117/12.2229766
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