17 September 2016 Fast and accurate detection of cancer cell using a versatile three-channel plasmonic sensor
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Abstract
Surface Plasmon Resonance (SPR) optical fiber sensors can be used as cost-effective small sized biosensors that are relatively simple to operate. Additionally, these instruments are label-free, hence rendering them highly sensitive to biological measurements. In this study, a three-channel microstructure optical fiber plasmonic-based portable biosensor is designed and analyzed using Finite Element Method. The proposed system is capable of determining changes in sample’s refractive index with precision of order one thousandth. The biosensor measures three absorption resonance wavelengths of the analytes simultaneously. This property is one of the main advantages of the proposed biosensor since it reduces the error in the measured wavelength and enhances the accuracy of the results up to 10-5 m/RIU by reducing noise. In this paper, Jurkat cell, an indicator cell for leukemia cancer, is considered as the analyte; and its absorption resonance wavelengths as well as sensitivity in each channel are determined.
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M. Hoseinian, M. Hoseinian, A. R. Ahmadi, A. R. Ahmadi, M. A. Bolorizadeh, M. A. Bolorizadeh, "Fast and accurate detection of cancer cell using a versatile three-channel plasmonic sensor", Proc. SPIE 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV, 992127 (17 September 2016); doi: 10.1117/12.2236357; https://doi.org/10.1117/12.2236357
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