Biomimetic tissue platform for photothermal cancer therapy using gold nanorods (GNRs)

Ki-Hwan Nam; Ji Yong Bae; Chan Bae Jeong; Gunhee Kim; Kye-Sung Lee; Ki-Soo Chang

doi:10.1117/12.2237227

13 September 2016 Biomimetic tissue platform for photothermal cancer therapy using gold nanorods (GNRs)

Ki-Hwan Nam, Ji Yong Bae, Chan Bae Jeong, Gunhee Kim, Kye-Sung Lee, Ki-Soo Chang

Proceedings Volume 9928, Nanobiosystems: Processing, Characterization, and Applications IX; 99280P (2016) https://doi.org/10.1117/12.2237227
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

Photothermal therapy (PT) provides a strong potential in treatment of tumors, selective cell death, through the ability of gold nanoparticles to target destructive heat preferentially to tumor regions. And yet, clinical application of the thermal therapies has not accomplished due to insufficient processes of the heating methods and temperature measuring techniques leading to low reproducibility of such treatment. In this study, we created a 3 dimensional tissue platform to characterize the heating method and to control the generated heat in the tissue used for a superficial cancer model using gold nanorods (GNRs) and near-infrared (NIR, 808 nm) laser. The 3D tissue platform involved a 2 mm wide hemisphere to confine the GNRs covered with20 μm thick polymer film designed to mimic localized nanoparticles in tumor. Moreover, this platform provides an easy way to measure heat distribution and temperature created in tumor cross section. To investigate the photothermal effect of GNRs on heat generation, the amount of GNRs and laser power density were controlled. The GNRs were shown to be the large absorption cross sections generating localized photothermal effects and hyperthermic effects on destructive consequences in the cell dynamics causing a partial tumor regression.

Citation Download Citation

Ki-Hwan Nam, Ji Yong Bae, Chan Bae Jeong, Gunhee Kim, Kye-Sung Lee, and Ki-Soo Chang "Biomimetic tissue platform for photothermal cancer therapy using gold nanorods (GNRs)", Proc. SPIE 9928, Nanobiosystems: Processing, Characterization, and Applications IX, 99280P (13 September 2016); https://doi.org/10.1117/12.2237227

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