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27 September 2016 Electrohydrodynamic direct printing on hydrogel: a novel method to obtain fine fibers
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In this study, we proposed a novel method to obtain fine fibers: electrohydrodynamic (EHD) direct printing PCL on hydrogel. The effects of applied voltage, flow rate, plotting speed, hydrogel viscosity on the EHD direct writing process were investigated to obtain the most appropriate set of process conditions. We also compared the fibers obtained from this method with traditional EHD which deposited on aluminum and ethanol-based collectors. We found that fibers collected on the hydrogel were thinner and exhibited pores on the surface due to the hydrogel’s facilitation of organic solvents’ volatilization in the PCL fibers, which can benefit the attachment of cells. Besides, in our previous study, we found the freeze-thaw crosslinking process could greatly increase mechanical properties of the hydrogel used in our research, so this integration will not only mimic the composition of ECM which is a composite structure with a combination of fibrous proteins within a gelatinous grounded substance but also improve the mechanical properties of the scaffold. This novel method will broaden the application of EHD technology in the field of tissue engineering and other related areas.
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Yuanyuan Liu, Chen Jiang, Yi Liu, Dongdong Li, and Qingxi Hu "Electrohydrodynamic direct printing on hydrogel: a novel method to obtain fine fibers", Proc. SPIE 9930, Biosensing and Nanomedicine IX, 993010 (27 September 2016);

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