26 September 2016 Microwave-to-terahertz dielectric resonators for liquid sensing in microfluidic systems
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Abstract
The microwave-to-terahertz frequency range offers unique opportunities for the sensing of liquids based on the degree of molecular orientational and electronic polarization, Debye relaxation due to intermolecular forces between (semi-)polar molecules and collective vibrational modes within complex molecules. Methods for the fast dielectric characterization of (sub-)nanolitre volumes of mostly aqueous liquids and biological cell suspensions are discussed, with emphasis on labon- chip approaches aimed towards single-cell detection and label-free flow cytometry at microwave-to-terahertz frequencies. Among the most promising approaches, photonic crystal defect cavities made from high-resistivity silicon are compared with metallic split-ring resonant systems and high quality factor (Q-factor) whispering gallery-type resonances in dielectric resonators. Applications range from accurate haemoglobin measurements on nanolitre samples to label-free detection of circulating tumor cells.
Conference Presentation
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N. Klein, C. Watts, S. M. Hanham, W. J. Otter, M. M. Ahmad, S. Lucyszyn, "Microwave-to-terahertz dielectric resonators for liquid sensing in microfluidic systems", Proc. SPIE 9934, Terahertz Emitters, Receivers, and Applications VII, 99340F (26 September 2016); doi: 10.1117/12.2238545; https://doi.org/10.1117/12.2238545
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