26 September 2016 Terahertz devices, spectroscopy, and signal processing for biosensing
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Abstract
Sub-wavelength metamaterial structures are of great fundamental and practical interest because of their ability to manipulate the propagation of electromagnetic waves. Here we investigate the metamaterials composed of titanium and copper split-ring resonators for use in detection of living cells. Terahertz spectroscopy was utilized to detect a change in resonance frequencies of the bio-sensor in the presence of MDA-MB-231 breast cancer cells in culture in real time. The shift in frequency showed dependency upon cell density. We applied circuit model to interpret the resonance peak shift observed, and not only do we see shifts in resonance frequency but also in capacitance and resistance as time progresses.
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Brianna Smiley, Brianna Smiley, Amanda Marotto, Amanda Marotto, Soner Balci, Soner Balci, Seung Jo Park, Seung Jo Park, M. Zeki Güngördü, M. Zeki Güngördü, Alex Maleski, Alex Maleski, A. Shahab Mollah, A. Shahab Mollah, Elizabath Philip, Elizabath Philip, Patrick Kung, Patrick Kung, Yonghyun Kim, Yonghyun Kim, Seongsin M. Kim, Seongsin M. Kim, } "Terahertz devices, spectroscopy, and signal processing for biosensing", Proc. SPIE 9934, Terahertz Emitters, Receivers, and Applications VII, 99340S (26 September 2016); doi: 10.1117/12.2238396; https://doi.org/10.1117/12.2238396
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