Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Frank Feyerabend; Thomas Dose; Yuling Xu; Felix Beckmann; Michael Stekker; Regine Willumeit-Römer; Andreas Schreyer; Fabian Wilde; Jörg U. Hammel

doi:10.1117/12.2241085

4 October 2016 Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Frank Feyerabend, Thomas Dose, Yuling Xu, Felix Beckmann, Michael Stekker, Regine Willumeit-Römer, Andreas Schreyer, Fabian Wilde, Jörg U. Hammel

Author Affiliations +

Proceedings Volume 9967, Developments in X-Ray Tomography X; 99671X (2016) https://doi.org/10.1117/12.2241085
Event: SPIE Optical Engineering + Applications, 2016, San Diego, California, United States

Abstract

The use of degradable magnesium based implants is becoming clinically relevant, e.g. for the use as bone screws. Still there is a lack of analyzing techniques to characterize the in vitro degradation behavior of implant prototypes. The aim of this study was to design an in situ environment to continuously monitor the degradation processes under physiological conditions by time-lapse SRμCT. The use of physiological conditions was chosen to get a better approach to the in vivo situation, as it could be shown by many studies, that these conditions change on the one hand the degradation rate and on the other hand also the formed degradation products. The resulting in situ environment contains a closed bioreactor system to control and monitor the relevant parameters (37°C, 5 % O₂, 20 % CO₂) and to grant sterility of the setup. A flow cell was designed and manufactured from polyether etherketone (PEEK), which was chosen because of the good mechanical properties, high thermal and chemical resistance and radiographic translucency. Sterilization of the system including the sample was reached by a transient flush with 70 % ethanol and subsequent replacement by physiological medium (Modified Eagle Medium alpha). As proof of principle it could be shown that the system remained sterile during a beamtime of several days and that the continuous SRμCT imaging was feasible.

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Frank Feyerabend, Thomas Dose, Yuling Xu, Felix Beckmann, Michael Stekker, Regine Willumeit-Römer, Andreas Schreyer, Fabian Wilde, and Jörg U. Hammel "Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography", Proc. SPIE 9967, Developments in X-Ray Tomography X, 99671X (4 October 2016); https://doi.org/10.1117/12.2241085

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