Antineoplastic And Antiviral Properties Of Merocyanine 540

Fritz Sieber

doi:10.1117/12.960195

17 March 1989 Antineoplastic And Antiviral Properties Of Merocyanine 540

Fritz Sieber

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960195
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

Simultaneous exposure to the lipophilic photosensitizer, merocyanine 540, and light in the presence of serum (or certain serum components) and oxygen kills leukemia cells, lymphoma cells, neuroblastoma cells, cell-free enveloped viruses, cell-associated enveloped viruses, and virus-infected cells. The same treatment spares pluripotent hematopoietic stem cells, mature erythrocytes, factor VIII, von Willebrand factor, and probably other blood components. Merocyanine 540-mediated photosensitization is now being evaluated clinically as a means to eliminate residual tumor cells from autologous remission bone marrow grafts and preclinically as a means to inactivate pathogenic viruses in blood products.

Citation Download Citation

Fritz Sieber "Antineoplastic And Antiviral Properties Of Merocyanine 540", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960195

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