28 September 2016 Mueller-matrix differentiation of fibrillar networks of biological tissues with different phase and amplitude anisotropy
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Abstract
The work consists of investigation results of diagnostic efficiency of a new azimuthally stable Mueller-matrix method of analysis of laser autofluorescence coordinate distributions of biological tissues histological sections. A new model of generalized optical anisotropy of biological tissues protein networks is proposed in order to define the processes of laser autofluorescence. The influence of complex mechanisms of both phase anisotropy (linear birefringence and optical activity) and linear (circular) dichroism is taken into account. The interconnections between the azimuthally stable Mueller-matrix elements characterizing laser autofluorescence and different mechanisms of optical anisotropy are determined. The statistic analysis of coordinate distributions of such Mueller-matrix rotation invariants is proposed. Thereupon the quantitative criteria (statistic moments of the 1st to the 4th order) of differentiation of histological sections of uterus wall tumor – group 1 (dysplasia) and group 2 (adenocarcinoma) are estimated.
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A. G. Ushenko, A. G. Ushenko, A. V. Dubolazov, A. V. Dubolazov, V. A. Ushenko, V. A. Ushenko, Yu. A. Ushenko, Yu. A. Ushenko, L. Ya. Kushnerick, L. Ya. Kushnerick, O. V. Olar, O. V. Olar, N. V. Pashkovskaya, N. V. Pashkovskaya, Yu. F. Marchuk, Yu. F. Marchuk, } "Mueller-matrix differentiation of fibrillar networks of biological tissues with different phase and amplitude anisotropy", Proc. SPIE 9971, Applications of Digital Image Processing XXXIX, 99712K (28 September 2016); doi: 10.1117/12.2237671; https://doi.org/10.1117/12.2237671
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