In the northwestern side of the São Paulo state, Brazil, irrigated areas are expanding, because rainfall is not enough to supply the crop water requirements. Under the actual climate and land-use change scenarios, large-scale evapotranspiration (ET) and biomass production (BIO) acquirements are relevant. Eleven Landsat 8 images, from May 2013 to October 2014, were used together with a net of eight agrometeorological stations for modelling these water productivity (WP) parameters in the main agricultural growing irrigated areas inside three hydrological basins in this region. Some of these areas inside of each basin were highlighted for more in-depth WP analyses. The SAFER algorithm estimated the ratio of actual (ET) to reference (ET0) evapotranspiration and this ratio was used for both, to calculate ET and to include the soil moisture effects in the Monteith’s Radiation Use Efficiency (RUE) model. The highlighted agricultural growing regions were Paranapuã, Populina and Santa Rita d’Oeste in the Turvo/Grande basin; Rubinéia, Santa Fé do Sul, Suzanópolis and Ilha Solteira, in the São José dos Dourados basin; and Pereira Barreto and Sud Mennucci, in the Baixo Tietê basin. The highest averages of both ET (1.7 ± 0.9 mm d-1) and BIO (47 ± 31 kg ha-1 d-1) were for Ilha Solteira, while the lowest ones happened in Sud Mennucci (1.3 ± 0.7 mm d-1 and 40 ± 27). These ET and BIO ranges returned WP values varying from 2.2 ± 0.6 to 2.6 ± 0.8 kg m-3, with the higher end of this range happening in the Turvo/Grande hydrological basin. Considering the annual time-scale, crops will consume around 770, 828 and 786 mm yr-1 with the corresponding BIO values of 27, 26 and 25 t ha-1 yr-1, respectively in Turvo/Grande, São José do Dourados and Baixo Tietê. It was concluded that increments in agricultural irrigated areas should be stimulated in the northwestern side of the state, mainly in the first basin, to retrieve good yield with less water use.