Assessing the birefringent tissue of the human tympanic membrane in vivo by fiber-based PSOCT

Svea Steuer; Jonas Golde; Lars Kirsten; Roberta Galli; Joseph Morgenstern; Marcus Neudert; Edmund Koch

doi:10.1117/12.2607217

7 March 2022 Assessing the birefringent tissue of the human tympanic membrane in vivo by fiber-based PSOCT

Svea Steuer, Jonas Golde, Lars Kirsten, Roberta Galli, Joseph Morgenstern, Marcus Neudert, Edmund Koch

Proceedings Volume PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022; PC1193501 (2022) https://doi.org/10.1117/12.2607217
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Endoscopic optical coherence tomography (eOCT), a depth-resolved, non-invasive, three-dimensional imaging technique, enables morphologic and functional examinations of the human tympanic membrane (TM) in vivo. To overcome the limitation of intensity-based OCT in tissue differentiation, light polarization is used here to assess collagen fibers as birefringent tissue. A fiber-based polarization-sensitive eOCT system was realized for first in vivo examinations of the TM’s collagen fiber layer, on which the acoustic and mechanical properties depend. By evaluating the local retardation, distinguishing the TM’s different tissues was possible and a comparison to microscopic ex vivo measurements was made.

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Svea Steuer, Jonas Golde, Lars Kirsten, Roberta Galli, Joseph Morgenstern, Marcus Neudert, and Edmund Koch "Assessing the birefringent tissue of the human tympanic membrane in vivo by fiber-based PSOCT", Proc. SPIE PC11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, PC1193501 (7 March 2022); https://doi.org/10.1117/12.2607217

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KEYWORDS

Optical coherence tomography

In vivo imaging

Tissues

Tissue optics

Collagen

Endoscopy

Light

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