Concerning the usage of non-invasive optical techniques for oral cancer detection, the presented study dealt with the manual and semi-automatic measurement of oral epithelial thickness by means of optical coherence tomography (OCT). Here, a total of 3,510 OCT images out of seven areas of the oral cavity was analyzed. In the result, epithelial thickness varied from 77 µm to 704 µm. Beyond that, there was a good correlation between both methods (ρ = 0.71-0.96). With regard to clinical routine use, manual epithelial thickness measurement could be beneficial due to a currently lower time investment with comparable precision.
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