Cardiac tissue substrate mapping with polarization-sensitive optical coherence tomography

Xiaowei Zhao; Ohad Ziv; Michael Douglass; Walter J. Hoyt; Michael W. Jenkins; Christopher Snyder; Christine P. Hendon; Kenneth Laurita; Andrew M. Rollins

doi:10.1117/12.2607820

7 March 2022 Cardiac tissue substrate mapping with polarization-sensitive optical coherence tomography

Xiaowei Zhao, Ohad Ziv, Michael Douglass, Walter J. Hoyt, Michael W. Jenkins, Christopher Snyder, Christine P. Hendon, Kenneth Laurita, Andrew M. Rollins

Author Affiliations +

Proceedings Volume PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022; PC1193606 (2022) https://doi.org/10.1117/12.2607820
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Atrial fibrosis is an important cause of atrial fibrillation (AF) and is often targeted for radiofrequency ablation (RFA) treatment. However, fibrosis identification during an RFA procedure is indirect and not well established. Polarization-sensitive optical coherence tomography (PSOCT) provides high-resolution in-depth noninvasive structural and tissue birefringence images, which can be effective for detecting fibrosis. In this work, combining histology and optical mapping of atrial action potential activity, we demonstrated the identification of atrial fibrosis that caused abnormal impulse propagation in a pig model of AF with PSOCT. Results indicate that PSOCT may provide effective guidance for RFA procedures in the future.

Conference Presentation

Citation Download Citation

Xiaowei Zhao, Ohad Ziv, Michael Douglass, Walter J. Hoyt, Michael W. Jenkins, Christopher Snyder, Christine P. Hendon, Kenneth Laurita, and Andrew M. Rollins "Cardiac tissue substrate mapping with polarization-sensitive optical coherence tomography", Proc. SPIE PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022, PC1193606 (7 March 2022); https://doi.org/10.1117/12.2607820

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available