Micromotor OCTA-FLIM catheter for cancer screening

Eric Brace; Scott Bernard; Jeanie Malone; Adrian Tanskanen; Anthony Lee; Catherine Poh; Pierre Lane

doi:10.1117/12.2609113

7 March 2022 Micromotor OCTA-FLIM catheter for cancer screening

Eric Brace, Scott Bernard, Jeanie Malone, Adrian Tanskanen, Anthony Lee, Catherine Poh, Pierre Lane

Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC1193706 (2022) https://doi.org/10.1117/12.2609113
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Fluorophores associated with early development of cancer (FAD, NADH, collagen) and abnormalities in microvessel structure have been shown to correlate with oral cancer progression. Co-registered imaging approaches using optical coherence tomography (OCT) and fluorescence imaging techniques have demonstrated promise in assessing these biomarkers, but current endoscopic approaches are limited in specificity. We propose that a micromotor-based OCT angiography and fluorescence-lifetime imaging microscopy (FLIM) may provide a suitable biopsy guidance tool for oral cancer screening. We present initial work towards implementing these modalities with a micromotor catheter system, validated with phantoms. Performance is compared to our existing OCT-autofluorescence system.

Conference Presentation

Citation Download Citation

Eric Brace, Scott Bernard, Jeanie Malone, Adrian Tanskanen, Anthony Lee, Catherine Poh, and Pierre Lane "Micromotor OCTA-FLIM catheter for cancer screening", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC1193706 (7 March 2022); https://doi.org/10.1117/12.2609113

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