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7 March 2022 Equivalent efficacy of indoor daylight and conventional ALA-PDT for treatment of actinic keratosis during winter
Alberto J. Ruiz, Ethan P. M. LaRochelle, Brady Hunt, Kimberley S. Samkoe, Brian W. Pogue, M. Shane Chapman
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Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2612347
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Indoor-daylight photodynamic therapy (PDT) for actinic keratoses (AKs) could overcome the treatment limitations associated with conventional lamp-based PDT and outdoor sunlight treatments. The objective of this study was to compare the AK lesion clearance efficacy of a conventional treatment (30 minute of 5-aminolevulinic acid [ALA] preincubation, followed by 10 minutes of red light) versus indoor daylight treatment (30 minute of ALA pre-incubation, followed by 2 hours of indoor sunlight). A prospective clinical trial was conducted with 43 patients. The results of the study indicate that indoor sunlight-based PDT provides equivalent AK treatment efficacy to a conventional lamp-based regimen while overcoming temperature limitations associated with winter season outdoor sunlight treatments.
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Alberto J. Ruiz, Ethan P. M. LaRochelle, Brady Hunt, Kimberley S. Samkoe, Brian W. Pogue, and M. Shane Chapman "Equivalent efficacy of indoor daylight and conventional ALA-PDT for treatment of actinic keratosis during winter", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2612347
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KEYWORDS
Photodynamic therapy
Clinical trials
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