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7 March 2022 Rationally designed light-activatable nanocomplex for multi-tier cancer cell targeting and photochemotherapy
Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, Huang-Chiao Huang
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Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2609687
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Combination treatments are most effective when targeting different cancer survival and growth pathways. Nanotechnology combined with photochemistry provides a unique opportunity to simultaneously deliver and activate multiple drugs that target all major regions of a cancer cell—plasma membrane, cytoplasm, and nucleus. In this study, we developed a light-activatable nanocomplex that selectively and simultaneously deliver three clinically relevant therapeutic agents at a synergistic drug ratio to destroy ovarian cancer cells, while sparing normal tissues.
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Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan, and Huang-Chiao Huang "Rationally designed light-activatable nanocomplex for multi-tier cancer cell targeting and photochemotherapy", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2609687
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KEYWORDS
Cancer
Oncology
Plasma
Optical imaging
Ovarian cancer
Photodynamic therapy
Proteins
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