Fast large area multiphoton exoscope (FLAME) for improving the detection accuracy of early melanoma

Mihaela Balu; Juvinch Vicente; Kristina Shrestha; Amanda F. Durkin; Christopher B. Zachary; Anand K. Ganesan; Kristen M. Kelly

doi:10.1117/12.2617030

7 March 2022 Fast large area multiphoton exoscope (FLAME) for improving the detection accuracy of early melanoma

Mihaela Balu, Juvinch Vicente, Kristina Shrestha, Amanda F. Durkin, Christopher B. Zachary, Anand K. Ganesan, Kristen M. Kelly

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Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC1194405 (2022) https://doi.org/10.1117/12.2617030
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Our group and others have demonstrated the strong potential of the multiphoton microscopy for a broad range of applications from advancing the understanding of skin biology to non-invasive diagnosis of skin diseases and monitoring therapy effects. We have recently reported on a fast large area multiphoton exoscope for rapidly mapping out macroscopic tissue areas with microscopic resolution and enhanced contrast for selective melanin detection. We will describe the technical abilities of this instrument and demonstrate its feasibility for early melanoma diagnosis based on a pilot study on ex-vivo and in-vivo imaging of pigmented lesions suspicious of melanoma in human skin.

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Mihaela Balu, Juvinch Vicente, Kristina Shrestha, Amanda F. Durkin, Christopher B. Zachary, Anand K. Ganesan, and Kristen M. Kelly "Fast large area multiphoton exoscope (FLAME) for improving the detection accuracy of early melanoma", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC1194405 (7 March 2022); https://doi.org/10.1117/12.2617030

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KEYWORDS

Melanoma

Skin

Collagen

Visualization

Optical fibers

Resolution enhancement technologies

Signal detection

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