3D optical coherence refraction tomography using a parabolic mirror

Kevin C. Zhou; Ryan P. McNabb; Ruobing Qian; Simone Degan; Al-Hafeez Dhalla; Sina Farsiu; Joseph A. Izatt

doi:10.1117/12.2611206

7 March 2022 3D optical coherence refraction tomography using a parabolic mirror

Kevin C. Zhou, Ryan P. McNabb, Ruobing Qian, Simone Degan, Al-Hafeez Dhalla, Sina Farsiu, Joseph A. Izatt

Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC119480W (2022) https://doi.org/10.1117/12.2611206
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Well-known limitations of optical coherence tomography (OCT) include deleterious speckle noise and relatively poor lateral resolution (typically >10 μm) due the tradeoff between lateral resolution and depth of focus. To address these limitations, we present 3D optical coherence refraction tomography (OCRT), which computationally combines 3D volumes from two rotational axes to form a 3D reconstruction with substantially reduced speckle noise and enhanced lateral resolution. Our approach features a parabolic mirror as the objective, which enables multi-view OCT volume acquisition over up to ±75° without moving the sample. We demonstrate 3D OCRT on a phantom sample and several biological samples, revealing new structures that are missed in conventional OCT.

Conference Presentation

Citation Download Citation

Kevin C. Zhou, Ryan P. McNabb, Ruobing Qian, Simone Degan, Al-Hafeez Dhalla, Sina Farsiu, and Joseph A. Izatt "3D optical coherence refraction tomography using a parabolic mirror", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480W (7 March 2022); https://doi.org/10.1117/12.2611206

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