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7 March 2022 Investigation of methods to extract confocal function parameters for depth resolved determination of attenuation coefficients using OCT in homogeneous and layered phantoms
Johannes Kübler, Vincent S. Zoutenbier, Arjen Amelink, Jörg Fischer, Johannes F. de Boer
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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194817 (2022) https://doi.org/10.1117/12.2610021
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The attenuation coefficient can be calculated from OCT data, but accurate determination requires compensating for the confocal function. We present detailed measurement series for extraction of the focal plane and the apparent Rayleigh length from the ratios of OCT images acquired with different focus depths and compare these results with alternative approaches. The optimal focus depth difference is determined for intralipid and titanium oxide phantoms with different scatterer concentrations and the attenuation coefficients corrected for the confocal function are calculated. We further demonstrate good reproducibility of the determined attenuation coefficient of layers with identical scatter concentrations in a multi-layered titanium oxide phantom.
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Johannes Kübler, Vincent S. Zoutenbier, Arjen Amelink, Jörg Fischer, and Johannes F. de Boer "Investigation of methods to extract confocal function parameters for depth resolved determination of attenuation coefficients using OCT in homogeneous and layered phantoms", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194817 (7 March 2022); https://doi.org/10.1117/12.2610021
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KEYWORDS
Optical coherence tomography
Signal attenuation
Confocal microscopy
Oxides
Titanium
Tissue optics
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