Single input polarization sensitive optical coherence tomography for imaging depth-resolved collagen organizations

Peijun Tang; Ruikang K. Wang; Mitchell A. Kirby; Nhan Le; Yuandong Li; Nicole Zeinstra; G. Nina Lu; Charles E. Murry; Ying Zheng

doi:10.1117/12.2612959

7 March 2022 Single input polarization sensitive optical coherence tomography for imaging depth-resolved collagen organizations

Peijun Tang, Ruikang K. Wang, Mitchell A. Kirby, Nhan Le, Yuandong Li, Nicole Zeinstra, G. Nina Lu, Charles E. Murry, Ying Zheng

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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194819 (2022) https://doi.org/10.1117/12.2612959
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

A novel polarization state tracing algorithm has been proposed to visualize depth-resolved birefringent information by using the polarization sensitive optical coherence tomography (PSOCT) system. This algorithm is compatible to the widely adopted single input PSOCT system which uses only one circularly polarized incident light. We demonstrate the ability of this method to visualize depth-resolved myocardial architecture in both healthy and infarcted rodent hearts (ex vivo) and collagen structures responsible for skin tension lines at various anatomical locations on the face of a healthy human volunteer (in vivo).

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Peijun Tang, Ruikang K. Wang, Mitchell A. Kirby, Nhan Le, Yuandong Li, Nicole Zeinstra, G. Nina Lu, Charles E. Murry, and Ying Zheng "Single input polarization sensitive optical coherence tomography for imaging depth-resolved collagen organizations", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194819 (7 March 2022); https://doi.org/10.1117/12.2612959

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KEYWORDS

Coherence imaging

Polarization

Collagen

Optical coherence tomography

Heart

Imaging systems

In vivo imaging

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