Rapid evaluations of laser cleaning efficacy on mature biofilm with microfluidic-powered optical platform

Van Nam Tran; Won Han; Fazlurrahman Khan; Van Gia Truong; Joong Ho Shin; Young Mog Kim; Hyun Wook Kang

doi:10.1117/12.2612147

7 March 2022 Rapid evaluations of laser cleaning efficacy on mature biofilm with microfluidic-powered optical platform

Van Nam Tran, Won Han, Fazlurrahman Khan, Van Gia Truong, Joong Ho Shin, Young Mog Kim, Hyun Wook Kang

Proceedings Volume PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; PC119580F (2022) https://doi.org/10.1117/12.2612147
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The aim of this study was to develop a microfluidic-powered optical platform to real-time monitor microbial biofilm formation at the single-cell level under a precisely controlled laminar flow condition and to rapidly evaluate the cleaning effect of laser irradiation on a mature microbial biofilm. A 405-nm laser light was used to evaluate the cleaning effects on both mature biofilms. The results show that Staphylococcus aureus biofilm was reduced by 80% in population, which was 20% higher than that of Candida albicans biofilm. A further study will be conducted in a poly-microbial biofilm commonly causing urinary tract infections.

Conference Presentation

Citation Download Citation

Van Nam Tran, Won Han, Fazlurrahman Khan, Van Gia Truong, Joong Ho Shin, Young Mog Kim, and Hyun Wook Kang "Rapid evaluations of laser cleaning efficacy on mature biofilm with microfluidic-powered optical platform", Proc. SPIE PC11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, PC119580F (7 March 2022); https://doi.org/10.1117/12.2612147

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