Brain fiber tracts imaging with polarized light: a potential navigation tool for tumor neurosurgery

Omar Rodriguez-Nunez; Philippe Schucht; Ekkehard Hewer; Tatiana Novikova; Angelo Pierangelo

doi:10.1117/12.2610129

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7 March 2022 Brain fiber tracts imaging with polarized light: a potential navigation tool for tumor neurosurgery

Omar Rodriguez-Nunez, Philippe Schucht, Ekkehard Hewer, Tatiana Novikova, Angelo Pierangelo

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Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC1196303 (2022) https://doi.org/10.1117/12.2610129
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Imaging Mueller polarimetry (IMP) was used in reflection geometry and large field of view configuration for the in-plane visualization of brain fiber tracts by exploring the anisotropy of the refractive index of healthy brain white matter. Our initial studies demonstrated that IMP successfully detects in-plane orientation of fiber tracts on a flat surface of the excised brain specimens. This work, performed ex-vivo on complete fresh calf brains proves the potential of IMP as a technique suitable to detect both presence and orientation of brain fiber tracts in the adverse conditions of complex surface topography and presence of blood.

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Omar Rodriguez-Nunez, Philippe Schucht, Ekkehard Hewer, Tatiana Novikova, and Angelo Pierangelo "Brain fiber tracts imaging with polarized light: a potential navigation tool for tumor neurosurgery", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC1196303 (7 March 2022); https://doi.org/10.1117/12.2610129

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