Detection of cervical collagen remodeling with Mueller polarimetry in mice model of pregnancy

Hee Ryung Lee; Ilyas Saytashev; Vinh Nguyen Du Le; Mala Mahendroo; Jessica Ramella-Roman; Tatiana Novikova

doi:10.1117/12.2610083

7 March 2022 Detection of cervical collagen remodeling with Mueller polarimetry in mice model of pregnancy

Hee Ryung Lee, Ilyas Saytashev, Vinh Nguyen Du Le, Mala Mahendroo, Jessica Ramella-Roman, Tatiana Novikova

Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC1196309 (2022) https://doi.org/10.1117/12.2610083
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Thin sections of uterine cervices from pregnant mice at day 6 and 18 of 19-days gestation period at different spatial locations along the cervices were studied with imaging Mueller polarimetry (IMP) combined with statistical analysis and multi-curve fit. The results suggest using depolarization and linear retardance images for collagen scoring and identification of cervical collagen changes during pregnancy. One day before delivery the remodeling of extracellular matrix of cervical collagen was detectable at the external cervical os, thus, proving that IMP modality may serve for the preterm birth risk assessment associated with the accelerated remodeling of cervical collagen.

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Citation Download Citation

Hee Ryung Lee, Ilyas Saytashev, Vinh Nguyen Du Le, Mala Mahendroo, Jessica Ramella-Roman, and Tatiana Novikova "Detection of cervical collagen remodeling with Mueller polarimetry in mice model of pregnancy", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC1196309 (7 March 2022); https://doi.org/10.1117/12.2610083

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KEYWORDS

Collagen

Polarimetry

Mouse models

Cervix

Optical fibers

Harmonic generation

Microscopy

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